Fresh analysis indicates that individuals who stop using popular weight-loss injections like semaglutide or tirzepatide may regain shed pounds far faster than those who stop traditional diet and exercise plans.
Findings released in a prominent health publication demonstrates that while obese people can lose a large proportion of their total mass while using the jabs, the weight is regained at an average rate of nearly a kilo each month once they quit.
"Individuals using such medications should be aware of the risk of fast rebound weight gain when the therapy is stopped," warns researcher Dr. Susan Jebb.
This pace of recovery implies a return to pre-treatment weight in about a year and a half.
Weighing Approaches
The research, which examined 37 of trials involving over 9,000 of patients, compared the effects of the injectable medications with older methods.
Researchers note that people who shed pounds through diet and exercise generally have a less rapid creep back—perhaps 0.1 kg a month—once they finish.
Understanding the Fast Rebound
Doctors propose the way of the injections is key to understanding the amplified regain.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Sustained high doses of the hormone concentrations far above than the body's typical production might result in the body to generate a reduced amount of its own natural GLP-1, and may also diminish responsiveness to its actions," noted Dr. Adam Collins, a dietetics specialist.
"Stopping of this GLP-1 'fix' means appetite is no longer kept in check, making overeating a significant risk."
A Chronic Issue?
The NHS suggest the injections for individuals with obesity-related medical conditions, alongside prescribed lifestyle changes.
A number of clinicians argue that, considering the significant potential of relapse, the therapy should be considered ongoing.
This view is echoed by pharmaceutical companies, who say that the results "underscore the persistent character of excess weight," similar to managing diseases like high blood pressure.
User Experiences
People who have stopped the jabs explain a sudden return of cravings.
"It was like something flipping and you're instantly ravenous," recalled a patient.
This difficulty is worsened if users have not established lasting lifestyle or habit modifications during treatment.
Growing Use
Figures suggest that a significant number of adults in the UK have used weight-loss jabs in the past year, with demand continuing to grow.
- Adoption is more common among females compared to men.
- The middle-aged demographic shows the highest level of interest.
- A large proportion access the drugs through private healthcare rather than the NHS.
Ultimately, experts stress that while the jabs are powerful tools for weight loss, they are not a magic solution and lasting health benefits likely depends on combined behavioural changes.
